Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note

A Novel Multicompartment Dissolution Apparatus for Evaluation of Floating Dosage Form Containing Poorly Soluble Weakly Basic Drug

Introduction Oral controlled release (CR) dosage forms generally have a transit time of 1–3 hours in the stomach,3–5 hours in the intestine and 4–11 hours in the colon(1). However,some drugs require more retention time in the stomach for better results. Gastro-retentive drug delivery is superior for drugs such as (a) drugs having a narrow absorption window,(b) drugs having their local effect in...

Suppository Dissolution Utilizing USP Apparatus

Standardized in-vitro dissolution testing of suppositories has been of interest to the pharmaceutical industry since the early works of Giabaldi and Gundhofer in 1975.(1) Anthony Palmieri exam ined standard izin g suppository dissolutions in his work at the University of Wyoming (2). Palmieri developed a slotted dissolution basket for suppositories that is ---------widely used by many individua...

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib

Calibration—the Usp Dissolution Apparatus Suitability Test

This report summarizes some trends observed in drug dissolution testing, based upon the United States Pharmacopeia (USP) dissolution Apparatus Suitability Test results and the preliminary data obtained from an international collaborative study to assess the pharmaceutical quality of furosemide products in different countries. Based on the USP calibrator data submitted by the participants, repre...

Experimental and Computational Study on Hydrodynamic of a Downscaled Mini Vessel USP Dissolution Test Apparatus II

Although not listed on the United States Pharmacopeia (USP), like standard USP 2, small volume USP 2 dissolution apparatus has gained a great deal of attention, especially for cases where small amount of drug product is available for testing in research and design step or evaluations are to be made on a tablet containing trace amounts of the active pharmaceutical ingredient. In this work, first...